METHOD FOR PRODUCING A PEPTIDE

摘要

Provided is a novel method for producing a peptide employing a ligation reaction, which shows more efficient ligation than prior native chemical ligation employing a thiol auxilliary group and does not tend to give rise to side reactions with other peptide functional groups. The method for producing a peptide includes a step of obtaining a product of linkage of a first peptide and a second peptide by reacting the first peptide and the second peptide in the presence of a reducing agent, wherein the first peptide includes an amino acid derivative, which has a thioester group, at the C terminus, and the second peptide includes a serine or threonine derivative, which has a thiol auxilliary group, at the N terminus.