发明名称 PHARMACEUTICAL FORMULATION 514
摘要 <p>The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H- phthalazin-1-one for increasing the bioavailability of the drug.</p>
申请公布号 CA2737400(A1) 申请公布日期 2010.04.15
申请号 CA20092737400 申请日期 2009.10.05
申请人 ASTRAZENECA UK LIMITED 发明人 BECHTOLD, MICHAEL KARL;PACKHAEUSER, CLAUDIA BETTINA;CAHILL, JULIE KAY;FASTNACHT, KATJA MAREN;LIEPOLD, BERND HARALD;LENNON, KIERAN JAMES;STEITZ, BENEDIKT
分类号 A61K9/20;A61K47/32 主分类号 A61K9/20
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