发明名称 |
INTEGRIN TARGETED CYCLOPEPTIDE LIGANDS, THEIR PREPARATION AND USE |
摘要 |
The present invention relates to novel hybrid cyclopeptide compounds embodying pyrrolidine- or piperidine-based amino acid substructures grafted onto a RGD (-Arg-Gly-Asp-) tripeptide sequence and acting as targeting ligands towards integrin receptors, intended, for example, for the treatment of altered angiogenic phenomena or for the preparation of therapeutically and/or diagnostically useful compounds; the invention also concerns a process for the synthesis of said cyclopeptides and biologically active derivatives thereof. |
申请公布号 |
US2010093612(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
US20080527603 |
申请日期 |
2008.02.19 |
申请人 |
CASIRAGHI GIOVANNI;BURREDDU PAOLA;MANZONI LEONARDO PIERPAOLO;SCOLASTICO CARLO;ZANARDI FRANCA;BATTISTINI LUCIA;CURTI CLAUDIO;RASSU GLORIA;AUZZAS LUCIANA |
发明人 |
CASIRAGHI GIOVANNI;BURREDDU PAOLA;MANZONI LEONARDO PIERPAOLO;SCOLASTICO CARLO;ZANARDI FRANCA;BATTISTINI LUCIA;CURTI CLAUDIO;RASSU GLORIA;AUZZAS LUCIANA |
分类号 |
A61K38/12;A61P9/10;A61P19/10;A61P35/00;C07K5/12 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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