发明名称 |
A USE OF THE LIQUIRITIGENIN ABUNDANT EXTRACT OR LIQUIRITIGENIN DERIVED THEREFROM FOR INCREASING BILE FLOW, CHOLERETIC EFFECT, AND FOR PREVENTING AND TREATING CHOLESTATIC LIVER DISEASES |
摘要 |
The present invention is related to a composition comprising an extract of licorice or liquiritigenin derived therefrom, which significantly increases bile flow rate and biliary excretion of bile acid, GSH and bilirubin. Consistent with these results, the inventive composition comprising an extract of licorice or liquiritigenin derived therefrom decrease the blood chemical markers including ALT as a hepatoprotective marker, and ALP and ?-GTP, as cholestatasis markers, and histochemical markers including central necrosis and inflammation in galactosamine/lipopolysaccharide-induced hepato-toxicity animal model when the inventive extract or compound of the present invention was orally and intravenously administrated thereto. |
申请公布号 |
WO2010041837(A2) |
申请公布日期 |
2010.04.15 |
申请号 |
WO2009KR05451 |
申请日期 |
2009.09.24 |
申请人 |
SNU R&DB FOUNDATION;KIM, SANG GEON;KIM, SANG CHAN;KIM, YOUNG WOO |
发明人 |
KIM, SANG GEON;KIM, SANG CHAN;KIM, YOUNG WOO |
分类号 |
A61K36/484 |
主分类号 |
A61K36/484 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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