New acetoxy-tetrahydroxy-7-methoxy-2-methyl-tetrahydroanthracen-9,10-dione and 8-(trihydroxy-7-methyl-2-methoxy-9,10-dioxo-anthracen-1-yl)-pentahydroxy-7-methoxy-2-methyl-tetrahydro-anthracen-9,10-dione, useful e.g. as antitumor agents

摘要

(1R,2S,3S,4R)-3-Acetoxy-1,2,4,5-tetrahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroanthracen-9,10-dione (I), and 8-(4,5,6-trihydroxy-7-methyl-2-methoxy-9,10-dioxo-9H,10H-anthracen-1-yl)-(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracen-9,10-dione (II), are new. Independent claims are included for: (1) the preparation of (I) or (II); and (2) the preparations of (I). ACTIVITY : Antibacterial; Fungicide; Virucide; Cytostatic. The antibacterial activity of (I) and (II) were tested in Streptococcus pneumoniaeusing in vitro assay. The results showed that the minimal inhibitory concentration of (I) and (II) was 7.8 mu g/ml. MECHANISM OF ACTION : None given.