发明名称 |
AMINE-CONTAINING COMPOUND ANALYSIS METHODS |
摘要 |
The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of isobaric tags, each isobaric tag comprising a reporter ion portion; (b) combining at least a portion of each of the isobarically labeled amine-containing compounds to produce a combined sample; (c) subjecting at least a portion of the combined sample to PDITM; (d) measuring the ion signal of one or more of the transmitted reporter ions; and (e) determining the concentration of one or more of the isobarically labeled amine-containing compounds based at least on a comparison of the measured ion signal of the corresponding reporter ion to one or more measured ion signals of a standard compound.
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申请公布号 |
US2010093011(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
US20090555319 |
申请日期 |
2009.09.08 |
申请人 |
LIFE TECHNOLOGIES CORPORATION |
发明人 |
NIMKAR SUBODH B.;PURKAYASTHA SUBHASISH;PAPPIN DARRYL;DANIELS SCOTT |
分类号 |
C12Q1/26;G01N33/00;G01N33/68 |
主分类号 |
C12Q1/26 |
代理机构 |
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主权项 |
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地址 |
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