QUINOLINE DERIVATIVES HAVING DP AND / OR CRTH2 RECEPTOR ACTIVITY

摘要

A compound of formula (I) for medicinal use: R1, R2, R3, R4 and R5 independently represent hydrogen, halogen, -S(O)nR6, -S(O)2NR7R8, -NR7S(O)2R6 -NR7R8, -NR7COR6, -CONR7R8, -COR6, - NO2, -CN, -OR7, C1-C6alkyl or C3-C7cycloalkyl, the latter two groups being optionally substituted by one or more fluoro atoms; R6 is C1-C6alkyl or C3-C7cycloalkyl, optionally substituted by one or more fluoro atoms; R7 and R8 independently represent hydrogen, C1-C6alkyl or C3-C7cycloalkyl, the latter two groups being optionally substituted by one or more fluoro atoms; A is -O-, -S(O)n, -CR9R10, -NR11 or -C(O); R9 and R10 independently represent a hydrogen, fluoro or C1-C6alkyl; R11 and R12 independently represent hydrogen or C1-C6alkyl; B is -C(R9R10)C(R9R10)- or C(R11)=C(R12); and when A is -CR9R10, B may additionally be -OCR9R10, -NR11CR9R10 or -S(O)nCR9R10; W is C1-C6alkyl optionally substituted by one or more substituents independently selected from fluoro, aryl, heteroaryl or C3-C7cycloalkyl, the latter group being optionally substituted with one or more fluoro atoms; and X is a carboxylic acid group, a tetrazolyl group, or a group of formula -CONHS(O)2R13 or -S(O)2NHCOR13; R13 is aryl, heteroaryl, C1-C6alkyl or C3-C7cycloalkyl, the latter two groups being optionally substituted by one or more fluoro atoms; and n is 0, 1 or 2.