发明名称 |
MODULATION OF MYELOID DIFFERENTATION PRIMARY RESPONSE GENE 88 (MYD88) EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES |
摘要 |
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of MyD88. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding MyD88. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding MyD88 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating MyD88 expression and for prevention or treatment of diseases wherein modulation of MyD88 expression would be beneficial are provided.
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申请公布号 |
US2010092486(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
US20090537354 |
申请日期 |
2009.08.07 |
申请人 |
IDERA PHARMACEUTICALS, INC. |
发明人 |
KANDIMALLA EKAMBAR;PUTTA MALLIKARJUNA;BHAGAT LAKSHMI;WANG DAQING;YU DONG;AGRAWAL SUDHIR |
分类号 |
A61K31/7105;A61K38/02;A61K39/00;A61K39/35;A61K39/395;A61P1/00;A61P3/10;A61P9/00;A61P11/06;A61P17/00;A61P25/18;A61P29/00;A61P37/06;C07H21/02 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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地址 |
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