发明名称 |
REGULATION OF APG8 PHOSPHORYLATION AND USES THEREOF |
摘要 |
The invention relates to proteins and peptides of the alpha isoform of light chain 3 (APG8) and antibodies to the APG8 protein, particularly antibodies that specifically bind to the alpha isoform of APG8 when either phosphorylated or not phosphorylated at serine-12 and antibodies that bind to the gamma isoform of APG8 when either phosphorylated or not phosphorylated at serine-9. The invention also relates to methods of producing these antibodies and use of these antibodies in the treatment of diseases related to autophagocytosis.
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申请公布号 |
US2010092458(A1) |
申请公布日期 |
2010.04.15 |
申请号 |
US20090505782 |
申请日期 |
2009.07.20 |
申请人 |
WU CHUN;MOUNTZOURIS JOHN A;HU BINGREN;LIU CHUNLI |
发明人 |
WU CHUN;MOUNTZOURIS JOHN A.;HU BINGREN;LIU CHUNLI |
分类号 |
A61K39/395;A61P43/00;C07K5/10;C07K5/103;C07K7/06;C07K7/08;C07K14/00;C07K16/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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