Described herein are implantable medical devices useful in treating vascular conditions such as restenosis. In one embodiment, stents are described in which a combination of bioactive agents is described for local delivery in the vasculature. The combination of bioactive agents comprises at least one compound capable of inhibiting smooth muscle cell proliferation and at least one compound capable of mitigating MCP-1 and/or TF induction. For example, a compound capable of inhibiting smooth muscle cell proliferation is a mTOR inhibitor and a compound capable of mitigating MCP-1 and/or TF induction is a corticosteroid.
申请公布号
WO2010042343(A2)
申请公布日期
2010.04.15
申请号
WO2009US58653
申请日期
2009.09.28
申请人
MEDTRONIC VASCULAR INC.;HEZI-YAMIT, AYALA;BILGE, I., MATT;WONG, JENNIFER;SULLIVAN, CAROL;VASQUEZ, NATIVIDAD
发明人
HEZI-YAMIT, AYALA;BILGE, I., MATT;WONG, JENNIFER;SULLIVAN, CAROL;VASQUEZ, NATIVIDAD