| 摘要 |
A compound, or its optical isomer, pharmaceutically acceptable salt, pharmaceutical product, N- oxide, hydrate or any combination thereof, represented by the structure of Formula VI:
wherein R 1 is hydrogen; R 2 is hydrogen, COOH, -C(=NH)-OH, -CH=CH 2 , hydroxyl, cyano, OCOR, alkenyl, OSO 2 CF 3 , or protected hydroxyl; R 3 , R 8 and R 9 are hydrogen; R 10 is hydrogen, halogen, CH=CHCO 2 H, CH=CHCO 2 R, -CH=CH 2 , cyano, aryl, 4-methoxyphenyl, 4-hydroxyphenyl, alkenyl, alkyl, or haloalkyl; R 11 is hydrogen, halogen, cyano, or SO 2 R; R 6 is hydrogen, halogen, or C 1 -C 6 -alkyl; R 7 is hydrogen or halogen; R' is hydrogen, Alk or COR; R" is hydrogen, Alk or COR; and R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, aryl, benzyl, halogen, alkenyl, CN, or NO 2 ; and Alk is a linear alkyl of 1-7 carbons, branched alkyl of 1-7 carbons, or cycloalkyl of 3-8 carbons; for use in treating, delaying onset, reducing the incidence of, or reducing the severity of a fatty liver condition in a subject. |
