METHODS FOR THE TREATMENT AND DIAGNOSIS OF CANCER

摘要

The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoKß) activity as well as to methods for the design of personalized therapies and for determining the response of an agent capable of inducing choline kinase beta (hereinafter ChoKß) for the treatment of cancer as well as to methods for determining the prognosis of a patient based on the determination of the ChoKß expression levels as well as based on the determination of the relationship between the ChoKß and ChoKa expression levels. Finally, the invention relates to methods for determining the response of a patient who suffers from cancer to ChoKa-inhibiting agents based on the determination of the PEMT and/or ChoKß expression levels.