| 摘要 |
Polypeptides and proteins comprising an IL-27RA cytokine binding domain operably linked to an immunoglobulin Fc fragment are disclosed. The Fc fragment is a modified Fc fragment wherein amino acid residues at EU index postions 234, 235, and 237 have been substituted to reduce binding to FcγRI and amino acid residues at EU index positions 330 and 331 have been substituted to reduce complement fixation. The proteins can be used medicinally for modulating immune responses, such as within methods of treating autoimmune diseases.
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