Pyranones useful as ATM inhibitors

摘要

The application concerns a compound of formula Ia:
and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein:
Y is O;
R 1 and R 2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 6 ring atoms;
R 3 is
wherein one of the phenyl rings in R 3 bear a substituent selected from the group consisting of acylamido, sulfonamino, ether, ester, amido and acyl.