A COMPOSITION COMPRISING THE DRIED LEAF POWDER OF BLACK PANAX GINSENG OR THE EXTRACT ISOLATED THEREFROM FOR PREVENTING AND TREATING PATHOGENIC AVIAN INFLUENZA VIRUS

摘要

PURPOSE: A linear double strand RNA molecule reducing expression of different target genes is provided to induce gene silence regardless of inversion orientation of siRNA. CONSTITUTION: A linear double strand RNA molecule contains 2-10 short interference RNAs(siRNA) which are serially connected. The siRNA comprises 18-24 nucleotides. The linear double strand RNA molecule contains two successive siRNAs. Each strand contains two 3'-terminal nucleotides which is not formed in base pair. A recombinant expression vector comprises double strand DNA sequence expressing the linear double strand RNA molecule. The expression of a target gene is suppressed by introducing the recombinant expression vector and linear type double strand RNA molecule in cells.