Homer1蛋白及其在治疗或预防脑损伤疾病中的应用

摘要

本发明公开了一种Homer1蛋白及其在治疗或预防脑损伤疾病中的应用，特别是涉及Homer1蛋白在治疗和预防脑损伤疾病中的一种或多种应用，该Homer1蛋白从人类cDNA基因库中扩增出其cDNA，并分别在原核和真核细胞中表达。经验证，Homer1蛋白可用于制备保护脑损伤的药物或神经保护剂，用于在脑损伤疾病中的的诊断、治疗和预防的应用，在哺乳动物细胞水平上作为蛋白药物治疗工具。

主权项

一种Homerl蛋白，其特征在于，该Homerl蛋白从人类cDNA基因库中扩增出其cDNA，并分别在原核和真核细胞中表达，其cDNA序列和蛋白序列如下：cDNA序列：ATGGGGGAACAACCTATCTTCAGCACTCTTCAGCACTCGAGCTCATGTCTTCCAAATTGACCCAAACACAAAGAAGAACTGGGTACCCACCAGCAAGCATGCAGTTACTGTGTCTTATTTCTATGACAGCACAAGAAATGTGTATAGGATAATCAGTTTAGATGGCTCAAAGGCAATAATAAATAGTACCATCACCCCAAACATGACATTTACTAAAACATCTCAGAAGTTTGGCCAGTGGGCTGATAGCCGGGCAAACACCGTTTATGGATTGGGATTCTCCTCTGAGCATCATCTTTCGAAATTTGCAGAAAAGTTTCAGGAATTTAAAGAAGCTGCTCGACTAGCAAAGGAAAAATCACAAGAGAAGATGGAACTTACCAGTACACCTTCACAGGAATCCGCAGGCGGGGATCTTCAGTCTCCTTTAACACCGGAAAGTATCAACGGGACAGATCGGGACAGATGATGAAAGAACACCTGATGTGACACAGAACTCAGAGCCAAGGGCTGAACCAACTCAGAATGCATTGCCATTTTCACATAGTTCAGCAATCAGCAAACATTGGGAGGCTGAACTGGCTACCCTCAAAGGAAATAATGCCAAACTCACTGCAGCCCTGCTGGAGTCCACTGCCAATGTGAAACAATGGAAACAGCAACTTGCTGCCTATCAAGAGGAAGCAGAACGTCTGCACAAGCGGGTGACTGAACTTGAATGTGTTAGTAGCCAAGCAAATGCAGTACATACTCATAAGACAGAATTAAATCAGACAATACAAGAACTGGAAGAGACACTGAAACTGAAGGAAGAGGAAATAGAAAGGTTAAAACAAGAAATTGATAATGCCAGAGAACTACAAGAACAGAGGGATTCTTTGACTCAGAAACTACAGGAAGTAGAAATTCGGAACAAAGACCTGGAGGGACAACTGTCTGACTTAGAGCAACGTCTGGAGAAAAGTCAGAATGAACAAGAAGCTTTTCGCAATAACCTGAAGACACTCTTAGAAATTCTGGATGGAAAGATATTTGAACTAACAGAATTACGAGATAACTTGGCCAAGCTACTAGAATGCAGCTAA蛋白序列：MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHS SAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS。