COMBINATION APPROACHES FOR GENERATING IMMUNE RESPONSES
摘要
<p>The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been shown to induce broad and potent neutralizing activity against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.</p>
申请公布号
EP1667631(A4)
申请公布日期
2010.04.14
申请号
EP20040788769
申请日期
2004.09.15
申请人
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;NATIONAL INSTITUTES OF HEALTH, NATIONAL CANCER INSTITUTE
发明人
BARNETT, SUSAN W.;GOMEZ-ROMAN, V.R.;LIAN, YING;PENG, BO;ROBERT-GUROFF, M.;SRIVASTAVA, INDRESH K.