PHARMACEUTICAL COMPOSITION, SUBSTRATE COMPRISING A PHARMACEUTICAL COMPOSITION, AND USE OF A PHARMACEUTICAL COMPOSITION

摘要

The invention relates to the use of a pharmaceutical composition for the local treatment of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises intracellular active antibiotics working as inhibitor of bacterial RNA polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B comprises extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilisation or rupture of the bacterial cell wall. The invention further relates to a related pharmaceutical composition and a substrate carrying a pharmaceutical composition.