发明名称 |
INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY |
摘要 |
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal. |
申请公布号 |
EP2173352(A2) |
申请公布日期 |
2010.04.14 |
申请号 |
EP20080772544 |
申请日期 |
2008.07.14 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
CHENG, JIN, Q.;SUN, MEI;SEBTI, SAID, M. |
分类号 |
C07D471/04;A61K31/519;A61K31/7068;A61P35/00;C07H19/23 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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