| 发明名称 |
HUMANIZED ANTIBODIES WITH MODIFIED GLYCOSYLATION |
| 摘要 |
The invention provides a method of reducing immunogenicity or toxicity of a therapeutic or diagnostic antibody in which a host system is selected for the characteristic that the system differentially glycosylatesan antibody or an antigen-binding antibody fragment, and a nucleotide sequence comprising nucleic acids encoding a therapeutic or diagnostic antibody is expressed in the host system.
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| 申请公布号 |
CA2257357(C) |
申请公布日期 |
2010.04.13 |
| 申请号 |
CA19972257357 |
申请日期 |
1997.06.06 |
| 申请人 |
NEORX CORPORATION |
发明人 |
GRAVES, SCOTT S.;RENO, JOHN M.;MALLET, ROBERT W.;HYLARIDES, MARK D.;SEARLE, STEPHEN M. J.;HENRY, ANDREW H.;PEDERSEN, JAN T.;REES, ANTHONY R. |
| 分类号 |
C07K16/46;G01N33/53;A61K38/00;A61K39/395;A61K47/48;A61K49/00;A61K51/10;A61P35/00;C07K1/113;C07K16/00;C07K16/30;C12N1/15;C12N1/19;C12N5/10;C12N15/09;C12P21/08;G01N33/574 |
主分类号 |
C07K16/46 |
| 代理机构 |
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