发明名称 |
Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1 |
摘要 |
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.
|
申请公布号 |
US7696308(B2) |
申请公布日期 |
2010.04.13 |
申请号 |
US20050144833 |
申请日期 |
2005.06.06 |
申请人 |
INSTITUT PASTEUR;NEW YORK UNIVERSITY |
发明人 |
LONGACRE-ANDRE SHIRLEY;ROTH CHARLES;NATO FARIDABANO;BARNWELL JOHN W.;MENDIS KAMINI |
分类号 |
A61K38/00;G01N33/569;A01N63/00;A61K39/00;A61K39/015;A61P33/06;C07H21/00;C07K14/445;C07K16/18;C07K16/20;C12N5/10;C12N5/24;C12N15/09;C12N15/30;C12N15/86;C12P21/02;C12P21/08;C12R1/01;C12R1/91;G01N33/577 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|