发明名称 |
GLYCOSAMINOGLYCANS DERIVED FROM K5 POLYSACCHARIDE HAVING HIGH ANTITHROMBIN ACTIVITY AND PROCESS FOR THEIR PREPARATION |
摘要 |
Glicosaminoglycans derived from K5 polysaccharide having high antithrombin activity and useful for the control of coagulation and as antithrombotic agents are obtained starting from an optionally purified K5 polysaccharide by a process comprising the steps of N-deacetylation/N-sulphation, C5 epimerisation of at least 40% of the glucuronic acid moiety, O-oversulphation, selective O-desuphation, 6-O-sulphation, N-sulphation, and optional depolymeration, and in which the selective O-desulphation step is carried out by treatment of the oversulphated product with a mixture dimethyl sulfoxide/methanol at a temperature of 50-70oC for 135-165 minutes. New, particularly interesting antithrombin compounds are obtained by thus controlling the reaction time in the selective O-desulphation step and submitting the product obtained at the end of the final N-sulphation step to depolymeration.
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申请公布号 |
CA2432150(C) |
申请公布日期 |
2010.04.13 |
申请号 |
CA20012432150 |
申请日期 |
2001.12.17 |
申请人 |
ORESTE, PASQUA;ZOPPETTI, GIORGIO |
发明人 |
ORESTE, PASQUA;ZOPPETTI, GIORGIO |
分类号 |
C08B37/10;C12P41/00;A61K31/726;A61K31/727;A61K31/737;A61P7/02;A61P9/10;C08B37/00 |
主分类号 |
C08B37/10 |
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