| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: group of inventions concerns medicine and pharmacology. There is offered an aqueous thermoset neutralised chitosan composition forming phosphate-free hydrogel at temperature 5C and higher which contains at total weight of the composition, 0.1-5.0% of reacetylated chitosan with molecular weight not less than 100 kDa and deacetylation degree 40 to 70% neutralised with a hydroxylated base, and 1-30% of a complex-making substance chosen from poliosis and originated polyols. There is offered lyophilisate prepared by lyophilisation of the aqueous thermoset neutralised chitosan composition. There is offered the method for preparing the aqueous thermoset neutralised chitosan composition. There is offered the method for preparing lyophilizate that involves lyophilisation of the aqueous thermoset neutralised chitosan composition. There is offered application of the aqueous thermoset neutralised chitosan composition and lyophilisate for making a drug delivery system, for making an injected dosage form. ^ EFFECT: invention provides preparing the aqueous thermoset neutralised chitosan composition forming phosphate-free hydrogel with improved properties and acceptable to biomedical application which is easily stored and maintains after-storage thermosetting properties. ^ 20 cl, 9 ex, 8 dwg |
