发明名称 |
COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF |
摘要 |
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine. |
申请公布号 |
WO2010037408(A1) |
申请公布日期 |
2010.04.08 |
申请号 |
WO2008EP08304 |
申请日期 |
2008.09.30 |
申请人 |
CUREVAC GMBH;FOTIN-MLECZEK, MARIOLA;VOSS, SOEHNKE |
发明人 |
FOTIN-MLECZEK, MARIOLA;VOSS, SOEHNKE |
分类号 |
A61K39/39;A61K47/00;A61P35/00 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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