发明名称 HIV INTEGRASE INHIBITORS
摘要 Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.
申请公布号 US2010087419(A1) 申请公布日期 2010.04.08
申请号 US20090572341 申请日期 2009.10.02
申请人 发明人 ISAACS RICHARD C. A.;THOMPSON WAYNE J.;WILLIAMS PETER D.;SU DAI-SHI;VENKATRAMAN SHANKAR;EMBREY MARK W.;FISHER THORSTEN E.;WAI JOHN S.;DUBOST DAVID C.;BALL RICHARD G.;CHOI ERIC J.;PEI TAO;TRICE SARAH L.;CAMPBELL NEIL;MADDESS MATTHEW;MALIGRES PETER E.;SHEVLIN MICHAEL;SONG ZHIGUO JAKE;STEINHUEBEL DIETRICH P.;STROTMAN NEIL A.;YIN JINGJUN
分类号 A61K31/553;A61K31/55;A61P31/18;C07D281/10;C07D487/04 主分类号 A61K31/553
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