| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a manufacturing method of a 4-halo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid or a salt thereof that does not require repeated extraction operations at a post-treatment stage, hardly accompanies a side reaction, is excellently operable, increases the total yield and is efficient. Ž<P>SOLUTION: In a reaction step, [1] a salt of pyrrolo[2,3-b]pyridine-7-oxide is isolated in a high yield; and [2] the 4-halo-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid or a salt thereof is obtained by causing a 4-halo-1H-pyrrolo[2,3-b]pyridine to react with carbon dioxide in the presence of a base thereby introducing in a high yield a carboxy group at the 5-position without by-producing a ketone compound. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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