<p>The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-mediated by an alkylating agent and a protic solvent or a mixture of a protic solvent and an aprotic solvent.</p>
申请公布号
WO2010039209(A2)
申请公布日期
2010.04.08
申请号
WO2009US05356
申请日期
2009.09.29
申请人
MALLINCKRODT INC.;WANG, PETER, X.;JIANG, TAO;BERBERICH, DAVID, W.