发明名称 |
HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS |
摘要 |
<p>Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.</p> |
申请公布号 |
CA2738925(A1) |
申请公布日期 |
2010.04.08 |
申请号 |
CA20092738925 |
申请日期 |
2009.10.01 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
SHARPLESS, NORMAN E.;STRUM, JAY C.;BISI, JOHN E.;ROBERTS, PATRICK J.;RAMSEY, MATTHEW R. |
分类号 |
A61K31/519;A61K31/407;A61P35/00 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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