发明名称 |
METHODS FOR PREDICTING PRODUCTION OF ACTIVATING SIGNALS BY CROSS-LINKED BINDING PROTEINS |
摘要 |
The present invention provides human binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL21R), and uses therefore. The invention further provides methods to predict whether the binding proteins of the invention may take on agonistic activities in vivo and produce a cytokine storm. In addition, the invention provides methods for determining whether an anti-IL21R binding protein is a neutralizing anti-IL21R binding protein, based on the identification of several IL21-responsive genes. The binding proteins can act as, e.g., antagonists of IL21R activity, thereby modulating immune responses in general, and those mediated by IL21R in particular. |
申请公布号 |
WO2010039533(A2) |
申请公布日期 |
2010.04.08 |
申请号 |
WO2009US58037 |
申请日期 |
2009.09.23 |
申请人 |
WYETH;O'TOOLE, MARGOT;GUO, YONGJING;RAMSEY, RENEE;BLOOM, LAIRD |
发明人 |
O'TOOLE, MARGOT;GUO, YONGJING;RAMSEY, RENEE;BLOOM, LAIRD |
分类号 |
A61K38/17;A61K38/20;C07K14/715;C07K16/28 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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