HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
摘要
<p>Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.</p>
申请公布号
WO2010037225(A1)
申请公布日期
2010.04.08
申请号
WO2009CA01387
申请日期
2009.09.30
申请人
MERCK FROSST CANADA LTD.;LECLERC, JEAN-PHILIPPE;LI, CHUN, SING;RAMTOHUL, YEEMAN, K.
发明人
LECLERC, JEAN-PHILIPPE;LI, CHUN, SING;RAMTOHUL, YEEMAN, K.