The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
申请公布号
WO2009137721(A3)
申请公布日期
2010.04.08
申请号
WO2009US43207
申请日期
2009.05.07
申请人
ZYSTOR THERAPEUTICS, INC.;LEBOWITZ, JONATHAN, H.;MAGA, JOHN