| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compounds which strongly binds to the EP<SB>2</SB>subtype among PGE receptors, and are useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, miscarriage, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, Still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia during dialysis, multiple organ failure, or bone diseases, etc. Ž<P>SOLUTION: The compounds are the 8-azaprostaglandin derivative compounds represented by formula (I-G), or pharmacologically acceptable salts thereof. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
|
