发明名称 |
Method for Treating Gefitinib Resistant Cancer |
摘要 |
The present invention is directed to methods for the treatment of gefitinib and/or erlotinib resistant cancer. An individual with cancer is monitored for cancer progression following treatment with gefitinib and/or erlotinib. Progression of the cancer is indicative that the cancer is resistant to gefitinib and/or erlotinib. Once progression of cancer is noted, the subject is administered a pharmaceutical composition comprising an irreversible epidermal growth factor receptor (EGFR) inhibitor. In preferred embodiments, the irreversible EGFR inhibitor is EKB-569, HKI-272 and HKI-357.
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申请公布号 |
US2010087482(A1) |
申请公布日期 |
2010.04.08 |
申请号 |
US20060883474 |
申请日期 |
2006.02.02 |
申请人 |
HABER DANIEL A;BELL DAPHNE WINIFRED;SETTLEMAN JEFFREY E;SORDELLA RAFFAELLA;GODIN-HEYMANN NADIA G;KWAK EUNICE L;RABINDRAN KRISHNA |
发明人 |
HABER DANIEL A.;BELL DAPHNE WINIFRED;SETTLEMAN JEFFREY E.;SORDELLA RAFFAELLA;GODIN-HEYMANN NADIA G.;KWAK EUNICE L.;RABINDRAN KRISHNA |
分类号 |
A61K31/4706;A61K31/4709;A61P35/00 |
主分类号 |
A61K31/4706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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