发明名称 |
A SEMI-SYNTHETIC PROCESS FOR THE PREPARATION OF N-DEBENZOYLPACLITAXEL |
摘要 |
<p>A process for the preparation of N- debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 is aryl or heteroaryl. The compound of formula (I) can be conveniently used for the preparation of paclitaxel and analogues.</p> |
申请公布号 |
KR20100036394(A) |
申请公布日期 |
2010.04.07 |
申请号 |
KR20107006006 |
申请日期 |
2003.03.24 |
申请人 |
INDENA S.P.A |
发明人 |
BOMBARDELLI EZIO;FONTANA GABRIELE |
分类号 |
C07D305/14;C07B51/00;C07B61/00;C07D263/04;C07D263/06;C07D413/12 |
主分类号 |
C07D305/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|