Process for the deacylation of cyclic lipopeptides

摘要

There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.
[wherein R 1 is acyl;
R 2 is hydroxy or acyloxy;
R 3 is hydrogen or hydroxy;
R 4 is hydrogen or hydroxy;
R 5 is hydrogen or hydroxysulfonyloxy; and
R 6 is hydrogen or carbamoyl.]