METHOD FOR TREATING DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION
摘要
The present invention relates to means and methods for therapeutic intervention of mitochondrial disorders or diseases, in particular to a method for the treatment, prevention and/or amelioration of a disorder or disease correlated with mitochondrial dysfunction, a mitochondrial disorder or disease or a disorder or disease characterized by an altered OPA1 processing. Thereby, a pharmaceutically active amount of a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof is administered to a patient in need of medical intervention. The present invention also relates to the use of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof for the preparation of a pharmaceutical composition for the mentioned therapeutic intervention. The present invention further relates to a method of screening for a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof comprising the use of OPA1.
申请公布号
EP2170374(A2)
申请公布日期
2010.04.07
申请号
EP20080773812
申请日期
2008.07.02
申请人
REICHERT, ANDREAS;DUVEZIN-CAUBET, STEPHANE;WAGENER, JOHANNES;ZICK, MICHAEL;LANGER, THOMAS;KOPPEN, MIRKO;NEUPERT, WALTER
发明人
REICHERT, ANDREAS;DUVEZIN-CAUBET, STEPHANE;WAGENER, JOHANNES;ZICK, MICHAEL;LANGER, THOMAS;KOPPEN, MIRKO;NEUPERT, WALTER