| 发明名称 |
Bryostatins for the treatment of Alzheimer's disease and cognitive enhancement |
| 摘要 |
The present invention relates to compositions to modulate alpha-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatment thereof through increased sAPP production. In the present invention PKC activators such as compounds of bryostatin or neristatin class are used for enhancing the cognitive ability. |
| 申请公布号 |
EP2172246(A2) |
申请公布日期 |
2010.04.07 |
| 申请号 |
EP20100000734 |
申请日期 |
2003.03.07 |
| 申请人 |
BLANCHETTE ROCKEFELLER NEUROSCIENCES, INSTITUTE |
发明人 |
ALKON, DANIEL L.;ETCHEBERRIGARAY, RENE |
| 分类号 |
A61K31/366;A61K45/00;A61K31/00;A61K31/365;A61K31/7048;A61P3/02;A61P3/08;A61P23/00;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P35/00;A61P39/02;A61P43/00 |
主分类号 |
A61K31/366 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
