发明名称 |
NUCLEASE-RESISTANT RNA APTAMER INHIBITING REPLICATION OF HEPATITIS C VIRUS REPLICON |
摘要 |
Disclosed is a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and includes at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 17, in which the fluoro group is substituted for the 2′-hydroxy of both the U (uracil) and the C (cytosine) bases, and which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection. |
申请公布号 |
EP2092078(A4) |
申请公布日期 |
2010.04.07 |
申请号 |
EP20070793124 |
申请日期 |
2007.06.08 |
申请人 |
BEXCORE CO., LTD.;DAEWON PHARM. CO., LTD. |
发明人 |
LEE, SEONG-WOOK;SHIN, KYUNG-SOOK;LIM, JONG-HOON;LEE, YOUNG-JOO;LEE, CHANG-HO |
分类号 |
C12N15/115 |
主分类号 |
C12N15/115 |
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