COMPOSITION CELLULAIRE IN VITRO À SUREXPRESSION SIMULTANÉE DE GÈNES HUMAINS MUTÉS PS1 M146V, APP SWE ET TAU P301L

摘要

Composition comprising primary cultures of cortical neurons obtainable from 3xTg-AD mouse embryos grown under depolarising conditions. Furthermore the invention relates to an in vitro method for evaluating the efficacy of compounds and materials to modify, treat or prevent diseases related with tau, amyloid-beta or APP pathology comprising the employment of primary cultures of cortical neurons obtainable from 3xTg-AD mouse embryos grown under depolarising conditions.