发明名称 |
PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS |
摘要 |
The present invention relates to new carboxylic acid amide derivatives of formula (I), wherein U, V, W, X, Y, Z, n and m are as defined as in Claim 1. A further object of the invention are the processes for producing of carboxylic acid amide compounds of formula (I), and the pharmaceutical manufacture of medicaments containing these compounds, as well as the process of treatments with these compounds, which means administering to a mammal to be treated including human - effective amount/amounts of compounds of formula (I) of the present invention as such or as medicament. The new carboxylic acid amide derivatives of formula (I) of the present invention are highly effective and selective antagonists of NMDA receptor, and moreover most of the compounds are selective antagonist of NR2B subtype of NMDA receptor.
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申请公布号 |
CA2453383(C) |
申请公布日期 |
2010.04.06 |
申请号 |
CA20022453383 |
申请日期 |
2002.07.23 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT |
发明人 |
DOMANY, GYOERGY;HORVATH, CSILLA;FARKAS, SANDOR;BARTANE SZALAI, GIZELLA;NAGY, JOZSEF;KOLOK, SANDOR;KOVACSNE BOZO, EVA;BORZA, ISTVAN;VAGO, ISTVAN;BIELIK, ATTILA;IGNACZNE SZENDREI, GYOERGYI;KESERU, GYOERGY |
分类号 |
C07D413/12;A61K;A61K31/445;A61K31/451;A61K31/454;A61K31/4545;A61K31/46;A61K31/4709;A61P;A61P3/10;A61P9/00;A61P11/06;A61P21/00;A61P21/04;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/32;A61P25/36;A61P27/02;A61P27/06;A61P27/16;A61P29/00;A61P31/12;A61P31/18;A61P43/00;C07D;C07D211/14;C07D211/16;C07D211/18;C07D401/06;C07D401/12;C07D417/12;C07D451/02 |
主分类号 |
C07D413/12 |
代理机构 |
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