发明名称 |
USE OF AROMATIC HYDROCARBONS AND SILICONE FLUIDS FOR MAKING BISPHOSPHONIC ACIDS |
摘要 |
Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phoshorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, a inert support or ortho-phosphoric acid codiluent is advantageously included.
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申请公布号 |
CA2485443(C) |
申请公布日期 |
2010.04.06 |
申请号 |
CA20032485443 |
申请日期 |
2003.05.19 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD |
发明人 |
LIDOR-HADAS, RAMI;HAREL, ZVI;LIFSHITZ-LIRON, REVITAL;KOVALEVSKI-ISHAI, ETI |
分类号 |
C07F9/38;C07F9/58;C07F9/6506;C07F9/6561 |
主分类号 |
C07F9/38 |
代理机构 |
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