发明名称 |
Three component chimeric antisense oligonucleotides |
摘要 |
This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
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申请公布号 |
US7691996(B2) |
申请公布日期 |
2010.04.06 |
申请号 |
US20050035693 |
申请日期 |
2005.01.14 |
申请人 |
LAKEWOOD-AMEDEX;SEQUITUR, INC. |
发明人 |
ARROW AMY;DALE RODERIC M. K.;WOOLF TOD MITCHELL |
分类号 |
C07H21/00;C07H21/02;C07H21/04;C12N15/113 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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