发明名称 |
Compositions and methods for inhibiting expression of a gene from the JC virus |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
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申请公布号 |
US7691824(B2) |
申请公布日期 |
2010.04.06 |
申请号 |
US20070741205 |
申请日期 |
2007.04.27 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
TAN PAMELA;SAH DINAH;BRAMLAGE BIRGIT |
分类号 |
A61K31/70;C07H21/04;C12N5/00;C12N15/00;C12N15/113 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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