发明名称 |
NEW PROCESS FOR PREPARATION OF ATOVAQUONE AND NOVEL INTERMEDIATES THEREOF |
摘要 |
Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as “Form IPCA-ATO,” and the preparation thereof.
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申请公布号 |
US2010081847(A1) |
申请公布日期 |
2010.04.01 |
申请号 |
US20090603253 |
申请日期 |
2009.10.21 |
申请人 |
KUMAR ASHOK;DIKE SUNEEL YESHWANT;MATHUR PRAMILKUMAR;BYJU NELLITHANATH THANKACHEN;SHARMA BRAJESH;KORE SWAPNIL SHREEKANT;BUCHUDE VITTHAL SURYABHAN;SINGH DHARMENDRA |
发明人 |
KUMAR ASHOK;DIKE SUNEEL YESHWANT;MATHUR PRAMILKUMAR;BYJU NELLITHANATH THANKACHEN;SHARMA BRAJESH;KORE SWAPNIL SHREEKANT;BUCHUDE VITTHAL SURYABHAN;SINGH DHARMENDRA |
分类号 |
C07C49/603;C07C45/61;C07C45/67 |
主分类号 |
C07C49/603 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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