SLOW RELEASE OF ORGANOBORONIC ACIDS IN CROSS-COUPLING REACTIONS
摘要
A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1-B-T; where R1 represents an organic group, T represents a conformationalIy rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a pal ladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.
申请公布号
WO2010036921(A2)
申请公布日期
2010.04.01
申请号
WO2009US58421
申请日期
2009.09.25
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;BURKE, MARTIN, D.;KNAPP, DAVID, M.;GILLIS, ERIC, P.
发明人
BURKE, MARTIN, D.;KNAPP, DAVID, M.;GILLIS, ERIC, P.