The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.
申请公布号
WO2009136976(A3)
申请公布日期
2010.04.01
申请号
WO2009US01085
申请日期
2009.02.20
申请人
AMGEN INC;BUDELSKY, ALISON, L.;COMEAU, MICHAEL, R.;TOCKER, JOEL, E.
