发明名称 |
SYNTHESIS OF FUNCTIONALIZED OCTAHYDRO-ISOQUINOLIN-1-ONE-8-CARBOXAMIDES, OCTAHYDRO-ISOQUINOLIN-1-ONE-8-CARBOXYLIC ESTERS AND ANALOGS, AND THERAPEUTIC METHODS |
摘要 |
A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels- Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl- containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject. |
申请公布号 |
WO2010037050(A2) |
申请公布日期 |
2010.04.01 |
申请号 |
WO2009US58647 |
申请日期 |
2009.09.28 |
申请人 |
UNIVERSITY OF KANSAS;AUBE, JEFFREY;ROTH, BRYAN, L.;GHOSH, PARTHA;FRANKOWSKI, KEVIN, J. |
发明人 |
AUBE, JEFFREY;ROTH, BRYAN, L.;GHOSH, PARTHA;FRANKOWSKI, KEVIN, J. |
分类号 |
C07D217/26;A61K31/472;A61P9/00;A61P13/00;C07D217/00;C07D217/22 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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地址 |
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