The present invention provides a method for preparing montelukast sodium salts of chemical formula 1 in the Description. The method of the present invention comprises the steps of: coupling the methanesulfonyl of chemical formula 2 and the compound of chemical formula 3 in the presence of bis(trimethylsilyl)amide alkali metal salts, adding an alkali metal base, and heating and hydrolyzing the resultant material to produce the compound of chemical formula 4; enabling a reaction between the compound of chemical formula 4 and 4-tert-butylcyclohexylamine and refining the resultant to produce the amine salts of chemical formula 5; and converting the amine salts into sodium salts.
申请公布号
WO2010036048(A2)
申请公布日期
2010.04.01
申请号
WO2009KR05472
申请日期
2009.09.25
申请人
LG LIFE SCIENCES, LTD.;LEE, IN SANG;LEE, SEOK JU;KANG, JAE EUN