PAUF-SPECIFIC HUMAN MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING THE SAME AND METHOD FOR DETECTING CANCER USING THE SAME

摘要

Disclosed are a PAUF protein associated with the onset of cancer, a human monoclonal antibody specific to the PAUF protein, and a nucleic acid molecule coding for the PAUF protein, and uses thereof. Closely correlated with the onset of cancer, the PAUF protein or the PAUF nucleic acid molecule can be used as a diagnostic marker or a therapeutic target. In addition, having the ability to bind specifically to PAUF presented on the surface of various cancer cells including pancreatic cancer cells, the anti-PAUF antibody or its functional fragment allows the diagnosis of cancer in the early stages thereof and can inhibit the growth, invasion or migration of cancer cells by inducing the cells to undergo apoptosis, and thus are useful in the diagnosis and treatment of cancer.