发明名称 |
STEM CELL EXPANSION ENHANCING FACTOR AND METHOD OF USE |
摘要 |
The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein.
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申请公布号 |
US2010080778(A1) |
申请公布日期 |
2010.04.01 |
申请号 |
US20090573489 |
申请日期 |
2009.10.05 |
申请人 |
SAUVAGEAU GUY;HUMPHRIES RICHARD KEITH |
发明人 |
SAUVAGEAU GUY;HUMPHRIES RICHARD KEITH |
分类号 |
A61K45/00;A61K38/00;A61K48/00;A61P37/04;C07K14/475;C12N5/074;C12N5/0789 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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